Information About IBRANCE for Targeted Treatment of Breast Cancer

IBRANCE is an oral medication used to treat some types of breast cancer. It is a brand-name drug with a typical dosage of 125 mg.

How Does IBRANCE Work?

IBRANCE contains palbociclib as the active ingredient. This endocrine therapy slows or stops the action of protein molecules that encourage cancer cell growth. Doctors often prescribe IBRANCE along with hormone therapy for breast cancer patients who don't have the HER-2 gene. Patients usually take this drug once a day for 21 days, then take a 7-day break before beginning another 28-day cycle. 

Is IBRANCE Chemotherapy?

IBRANCE is different from standard chemotherapy. It is a targeted therapy called a CDK 4/6 inhibitor. Because this type of drug stops the growth of healthy cells while fighting off cancer cells, many people experience similar side effects as experienced with chemotherapy.

IBRANCE Side Effects

If your doctor puts you on IBRANCE for breast cancer treatment, you may experience dry skin, fatigue, weakness, sores or irritation in the mouth, diarrhea, loss of appetite, hair thinning or loss, and nausea and vomiting. Your healthcare team can prescribe other medications to help with the side effects you might experience while on this cancer drug.

Talk to your healthcare provider right away if you develop nonhealing wounds, sores in the mouth, pain during urination, excessive or discolored mucus, uncontrolled cough, sinus or ear pain, sore throat, chills or fever. Wash your hands often to prevent infection while taking IBRANCE. You should use birth control to avoid getting pregnant when taking this medication as it can cause fetal harm. 

Does Medicare Cover IBRANCE?

Most Medicare prescription drug plans cover IBRANCE as long as your healthcare provider says it is medically necessary. This includes both Medicare Part D and Advantage plans. However, you may need to meet a deductible before the plan starts paying for your medication. The maximum annual prescription drug deductible for Medicare is $545 in 2024. Without coverage, IBRANCE may cost between $3,409 and $13,635.